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J Neurosurg Spine. 2018 Nov 1;29(5):599-607. doi: 10.3171/2018.4.SPINE171164.

Effects of silk solution against laminectomy-induced dural adhesion formation and inflammation in a rat model.

Author information

1
1Department of Neurosurgery, Hallym University Medical Center, Chuncheon.
2
2Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon.
3
3Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung; and.
4
4Department of Oral Anatomy, College of Dentistry and Research Institute of Oral Biology, Gangneung-Wonju National University, Gangneung, Korea.

Abstract

The authors investigated the effects of a silk solution against laminectomy-induced dural adhesion formation and inflammation in a rat model. They found that it significantly reduced postlaminectomy dural adhesion formation and inflammation. Dural adhesion formation, thought to be an inevitable consequence of laminectomy, is one of the most common complications following spinal surgery, and the authors' results indicate that the silk solution might be a potential novel therapeutic agent for dural adhesion formation.

KEYWORDS:

COX-2 = cyclooxygenase-2; IL = interleukin; MMP = matrix metalloproteinase; antiadhesion; iNOS = inducible nitric oxide synthase; inflammation; laminectomy; rat; silk solution

PMID:
30141762
DOI:
10.3171/2018.4.SPINE171164
[Indexed for MEDLINE]

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