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Phys Med. 2018 Aug;52:122-128. doi: 10.1016/j.ejmp.2018.07.005. Epub 2018 Jul 20.

Performance evaluation of the LightPath imaging system for intra-operative Cerenkov luminescence imaging.

Author information

1
University of Pisa, Department of Physics, Largo Bruno Pontecorvo 3, Pisa 56127, Italy. Electronic address: esther.ciarrocchi@df.unipi.it.
2
University of Ghent, IBiTech-MEDISIP, C. Heymanslaan 10, Ghent B-9000, Belgium. Electronic address: christian.vanhove@ugent.be.
3
University of Ghent, IBiTech-MEDISIP, C. Heymanslaan 10, Ghent B-9000, Belgium. Electronic address: benedicte.descamps@ugent.be.
4
University of Ghent, Faculty of Pharmaceutical Sciences Laboratory of Radiopharmacy, Ottergemsesteenweg 460, Ghent B-9000, Belgium. Electronic address: stef.delombaerde@ugent.be.
5
University of Ghent, IBiTech-MEDISIP, C. Heymanslaan 10, Ghent B-9000, Belgium. Electronic address: stefaan.vandenberghe@ugent.be.
6
University of Pisa, Department of Physics, Largo Bruno Pontecorvo 3, Pisa 56127, Italy. Electronic address: nicola.belcari@unipi.it.

Abstract

The performances of an intra-operative optical imaging system for Cerenkov luminescence imaging of resected tumor specimens were evaluated with phantom studies. The spatial resolution, the linearity of the measured signal with the activity concentration and the minimum detectable activity concentration were considered. A high linearity was observed over a broad range of activity concentration (R2⩾0.99 down to ∼40 kBq/ml of 18F-FDG). For 18F-FDG activity distributions 2 mm deep in biological tissue, the measured detection limit was 8 kBq/ml and a spatial resolution of 2.5 mm was obtained. The detection limit of the imaging system is comparable with clinical activity concentrations in tumor specimens, and the spatial resolution is compatible with clinical requirements.

KEYWORDS:

Beta-emitting radiotracer; Cerenkov luminescence imaging; Intra-operative imaging; Performance evaluation

PMID:
30139600
DOI:
10.1016/j.ejmp.2018.07.005
[Indexed for MEDLINE]

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