Format

Send to

Choose Destination
Stem Cell Res Ther. 2018 Aug 23;9(1):225. doi: 10.1186/s13287-018-0973-3.

Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury.

Zhao L1,2,3, Hu C4, Zhang P1,2,3, Jiang H1,2,3, Chen J5,6,7.

Author information

1
Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
2
Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, Zhejiang Province, People's Republic of China.
3
Institute of Nephrology, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
4
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
5
Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China. zjukidney@zju.edu.cn.
6
Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, Zhejiang Province, People's Republic of China. zjukidney@zju.edu.cn.
7
Institute of Nephrology, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China. zjukidney@zju.edu.cn.

Abstract

Acute kidney injury (AKI) remains a worldwide public health issue due to its increasing incidence, significant mortality, and lack of specific target-orientated therapy. Developments in mesenchymal stem cell (MSC) research make MSCs a promising candidate for AKI management but relevant clinical trials show confusing results (NCT00733876, NCT01602328). One primary cause of the limited therapeutic effect may result from poor engraftment of transplanted cells. To solve this problem, investigators have developed a series of preconditioning strategies to improve MSC engraftment in animal AKI models. In this review, we summarize these previous studies, providing an integrated and updated view of different preconditioning strategies aimed at promoting the therapeutic effect of MSCs in AKI patients.

KEYWORDS:

Acute kidney injury; Mesenchymal stem cells; Migratory ability; Preconditioning strategy

PMID:
30139368
PMCID:
PMC6108125
DOI:
10.1186/s13287-018-0973-3
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center