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J Med Food. 2018 Aug 23. doi: 10.1089/jmf.2018.4183. [Epub ahead of print]

Beneficial Effects of Hesperetin in a Mouse Model of Temporal Lobe Epilepsy.

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1 BK21 Plus KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University , Daegu, Korea.
2 Department of Food Science and Nutrition, Pukyong National University , Busan, Korea.
3 Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine , Daejeon, Korea.
4 Department of Microbiology, School of Medicine, Kyungpook National University , Daegu, Korea.
5 Department of Biology Education, Kyungpook National University , Daegu, Korea.
6 Brain Science and Engineering Institute, Kyungpook National University , Daegu, Korea.


Abnormal reorganization of the dentate gyrus and neuroinflammation in the hippocampus represent characteristic phenotypes of patients suffering from temporal lobe epilepsy. Hesperetin, a flavanone abundant in citrus fruit, is known to have protective effects by preventing inflammation and oxidative stress in neuronal cultures and in the adult murine brain. However, the protective effects of hesperetin against epileptic seizures in vivo remain unclear, despite one study reporting anticonvulsant effects in vitro. In this study, we report that oral administration of hesperetin not only delays the onset of seizures triggered by kainic acid (KA) but also contributes to the attenuation of granule cell dispersion in the KA-treated hippocampus. Moreover, we observed that hesperetin administration inhibited the expression of pro-inflammatory molecules produced by activated microglia in the hippocampus. Thus, administration of hesperetin might be beneficial for preventing epileptic seizures.


granule cell dispersion; hesperetin; neuroinflammation; temporal lobe epilepsy


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