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Version 2. F1000Res. 2018 Aug 1 [revised 2018 Sep 10];7. pii: F1000 Faculty Rev-1169. doi: 10.12688/f1000research.15064.2. eCollection 2018.

Recent advances in understanding the complexities of metastasis.

Author information

1
Garvan Institute of Medical Research & the Kinghorn Cancer Centre, Cancer Division, Sydney, NSW, 2010, Australia.
2
St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW , 2010, Australia.
#
Contributed equally

Abstract

Tumour metastasis is a dynamic and systemic process. It is no longer seen as a tumour cell-autonomous program but as a multifaceted and complex series of events, which is influenced by the intrinsic cellular mutational burden of cancer cells and the numerous bidirectional interactions between malignant and non-malignant cells and fine-tuned by the various extrinsic cues of the extracellular matrix. In cancer biology, metastasis as a process is one of the most technically challenging aspects of cancer biology to study. As a result, new platforms and technologies are continually being developed to better understand this process. In this review, we discuss some of the recent advances in metastasis and how the information gleaned is re-shaping our understanding of metastatic dissemination.

KEYWORDS:

Biosensors; Cancer; Cancer Therapy; Circulating Tumour Cells; Colonisation; Disseminated Tumour Cells; Dormancy; Extracellular Matrix; Extravasation; Intravasation; Intravital Imaging; Invasion; Metastasis; Microenvironment; Migration; Mouse Models; Tumour Stroma

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