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Antibiotics (Basel). 2018 Aug 22;7(3). pii: E79. doi: 10.3390/antibiotics7030079.

Silver and Antibiotic, New Facts to an Old Story.

Author information

1
Laboratoire de Chimie Bactérienne (LCB), Institut de Microbiologie de la Méditerranée (IMM), Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), 13009 Marseille, France. fbarras@pasteur.fr.
2
Département de Microbiologie, Institut Pasteur, 75015 Paris, France. fbarras@pasteur.fr.
3
Laboratoire de Chimie Bactérienne (LCB), Institut de Microbiologie de la Méditerranée (IMM), Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), 13009 Marseille, France. aussel@imm.cnrs.fr.
4
Laboratoire de Chimie Bactérienne (LCB), Institut de Microbiologie de la Méditerranée (IMM), Aix Marseille Université, Centre National de la Recherche Scientifique (CNRS), 13009 Marseille, France. ezraty@imm.cnrs.fr.

Abstract

The therapeutic arsenal against bacterial infections is rapidly shrinking, as drug resistance spreads and pharmaceutical industry are struggling to produce new antibiotics. In this review we cover the efficacy of silver as an antibacterial agent. In particular we recall experimental evidences pointing to the multiple targets of silver, including DNA, proteins and small molecules, and we review the arguments for and against the hypothesis that silver acts by enhancing oxidative stress. We also review the recent use of silver as an adjuvant for antibiotics. Specifically, we discuss the state of our current understanding on the potentiating action of silver ions on aminoglycoside antibiotics.

KEYWORDS:

ROS; adjuvant; antibiotics; combinatorial; metal; silver

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