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Viruses. 2018 Aug 21;10(9). pii: E447. doi: 10.3390/v10090447.

Who's Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling.

Author information

1
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA. Christopher_Goodwin@URMC.Rochester.edu.
2
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA. Jessica_Ciesla@URMC.Rochester.edu.
3
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA. josh.munger@rochester.edu.

Abstract

As essential components of the host's innate immune response, NFκB and interferon signaling are critical determinants of the outcome of infection. Over the past 25 years, numerous Human Cytomegalovirus (HCMV) genes have been identified that antagonize or modulate the signaling of these pathways. Here we review the biology of the HCMV factors that alter NFκB and interferon signaling, including what is currently known about how these viral genes contribute to infection and persistence, as well as the major outstanding questions that remain.

KEYWORDS:

HCMV; ISG; IκB kinase (IKK); NFκB; human cytomegalovirus; interferon

PMID:
30134546
PMCID:
PMC6163874
DOI:
10.3390/v10090447
[Indexed for MEDLINE]
Free PMC Article

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