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Virchows Arch. 2019 Jan;474(1):105-109. doi: 10.1007/s00428-018-2437-7. Epub 2018 Aug 21.

CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas.

Author information

1
ARC-Net Research Center, University of Verona, Verona, Italy.
2
Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134, Verona, Italy.
3
Department of General and Visceral Surgery, Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
4
Personalized Medicine, Pharmacogenomics, Therapeutic Optimization, Paris-Descartes University, Paris, France.
5
Department of Surgery, Section of Pathology, San Bortolo Hospital, Vicenza, Italy.
6
ARC-Net Research Center, University of Verona, Verona, Italy. aldo.scarpa@univr.it.
7
Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134, Verona, Italy. aldo.scarpa@univr.it.

Abstract

CD200 has been recently indicated as a robust marker of well-differentiated neuroendocrine neoplasms. Here, we evaluate its role in differential diagnosis of solid pancreatic neoplasms. We immunostained for CD200 22 solid pseudopapillary neoplasms (SPNs), 8 acinar carcinomas (ACs), 2 pancreatoblastomas (PBs), 138 neuroendocrine tumors (PanNETs), and 48 ductal adenocarcinomas. All SPNs showed strong cytoplasmic and membranous staining for CD200, while only one case of AC had focal positivity. The two PBs showed focal CD200 positivity, mainly located in squamoid nests. The vast majority of PanNETs (96%) showed strong cytoplasmic and membranous staining for CD200, whereas all PDACs were negative. As both PanNETs and SPNs express CD200, it has no role in the differential diagnosis between these two entities.

KEYWORDS:

Acinar carcinoma; CD200; Immunohistochemistry; Pancreatic cancer; SPN; SPT

PMID:
30132130
PMCID:
PMC6323071
DOI:
10.1007/s00428-018-2437-7
[Indexed for MEDLINE]
Free PMC Article

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