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Dev Cell. 2018 Aug 20;46(4):389-396. doi: 10.1016/j.devcel.2018.08.003.

Coming to Consensus: A Unifying Model Emerges for Convergent Extension.

Author information

1
Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
2
Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA. Electronic address: wallingford@austin.utexas.edu.

Abstract

Cell motility is a widespread biological property that is best understood in the context of individual cell migration. Indeed, studies of migration in culture have provided tremendous insight into the signals and mechanics involved and have laid the foundation for our understanding of similar migrations by larger cellular collectives. By contrast, our understanding of another flavor of movement, cell intercalation during convergent extension, is only now emerging. Here, we integrate divergent findings related to intercalation in different settings into a unifying model, paying attention to how this model does and does not resemble current models for directed cell migration.

PMID:
30130529
PMCID:
PMC6140352
[Available on 2019-08-20]
DOI:
10.1016/j.devcel.2018.08.003
[Indexed for MEDLINE]

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