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PLoS One. 2018 Aug 21;13(8):e0201840. doi: 10.1371/journal.pone.0201840. eCollection 2018.

Vitamin D status and functional parameters: A cross-sectional study in an older population.

Author information

1
Department of Biomedicine, Biochemistry Unit, Faculty of Medicine, University of Porto, Porto, Portugal.
2
I3S - Institute for Research and Innovation in Health, University of Porto, Porto, Portugal.
3
Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal.
4
CINTESIS - Centre for Health Technology and Services Research, Porto, Portugal.
5
EPIUnit, Institute of Public Health, University of Porto, Porto, Portugal.
6
The Research Centre in Physical Activity, Health and Leisure, University of Porto, Porto, Portugal.
7
System Integration and Process Automation Unit (UISPA), Mechanical Engineering Institute (IDMEC), Faculty of Engineering, University of Porto, Porto, Portugal.

Abstract

The present study aims to clarify the association of vitamin D status with functionality, measured through gait speed and hand grip strength, in a sample of older adults, considering sex-specific characteristics and the potential confounding effect of lifestyle factors, disease, skin phenotype, season of blood collection and vitamin D supplementation. The Nutrition UP 65 cross-sectional study was conducted in a population-based sample of 1,425 older adults ≥ 65 years old. Serum levels of 25-hydroxyvitamin D were quantified through electrochemiluminescence immunoassay. Multinomial logistic regressions were carried out using quartiles of gait speed and of hand grip strength as dependent variables. Participants at risk of vitamin D inadequacy (30.0-49.9 nmol/L) and deficiency (< 30.0 nmol/L) presented higher adjusted odds ratio of the lowest values of gait speed and hand grip strength than those with adequate vitamin D levels (≥ 50.0 nmol/L). These associations were strongest among men at risk of vitamin D deficiency [adjusted odds ratio for the lowest quartile of gait speed = 3.24; 95% CI: 1.56-6.73 and for the lowest quartile of hand grip strength = 3.28; 95% CI: 1.47-7.31] than in women at risk of vitamin D deficiency [adjusted odds ratio for the lowest quartile of gait speed = 2.72; 95% CI: 1.37-5.41 and for the lowest quartile of hand grip strength = 1.56; 95% CI: 0.81-3.00]. In conclusion, in older adults, particularly in men, the risk of vitamin D deficiency was directly associated with the lowest values of gait speed and of hand grip strength. However, randomized controlled trials are needed to overcome the possibility of reverse causation and residual confounding. Present results emphasise the need for strategies to promote the reduction of the high prevalence of low vitamin D status among the Portuguese older adult population.

PMID:
30130370
PMCID:
PMC6103509
DOI:
10.1371/journal.pone.0201840
[Indexed for MEDLINE]
Free PMC Article

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