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Gynecol Endocrinol. 2019 Jan;35(1):58-61. doi: 10.1080/09513590.2018.1499086. Epub 2018 Aug 21.

Effects of a combination of Nigella sativa and Vitex agnus-castus with citalopram on healthy menopausal women with hot flashes: results from a subpopulation analysis.

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a Department of Clinical Pharmacy, Faculty of Pharmacy, Pharmaceutical Science Branch , Islamic Azad University, IAUPS , Tehran , Iran.
b Pharmacology Department, School of Medicine , Iran University of Medical Sciences , Tehran , Iran.
c Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences , Islamic Azad University of Tehran , Tehran , Iran.
d Maternal, Fetal and Neonatal Research Center , Tehran University of Medical Sciences , Tehran , Iran.
e Department of Pharmacognosy and Medicinal Plant Research Center, School of Pharmacy , Tehran University of Medical Sciences , Tehran , Iran.


The goal of the current study was to evaluate the efficiency of a phytotherapeutic intervention consisting of a combination of Nigella sativa and Vitex agnus-castus with citalopram in the control of hot flashes in healthy menopausal women. An 8 week, double-blind, randomized, placebo-controlled study was performed among 46 women aged between 40 and 60 years experiencing an average of more than four hot flashes per day recruited during July 2016 to June 2017. Data on severity of vasomotor symptoms were collected at the end of the eighth week. Herbal medication or placebo capsules were administered once daily in morning. At the end of the 8-week treatment period, analyses of covariance demonstrated the superiority of herbal combination with citalopram over placebo and citalopram for three MENQOL domain scores including vasomotor (p < .001), physical (p = .036), psychosocial (p = .001) but no significant differences were observed in terms of sexual function (p = .231). Based on the results, the addition of a combination of N. sativa and V. agnus-castus to the citalopram may be a potential clinical application for improving therapeutic outcomes. Larger randomized, controlled trials are also warranted for further investigations of these symptoms.


; MENQOL scores; citalopram; hot flashes

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