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Curr Pharm Biotechnol. 2018;19(8):644-663. doi: 10.2174/1389201019666180821093239.

Apoptosis: Mediator Molecules, Interplay with Other Cell Death Processes and Therapeutic Potentials.

Author information

1
Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India.
2
Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas 75204, United States.
3
School of Biochemical Engineering, Indian Institute of Technology (BHU) Varanasi, Varanasi 221005, India.

Abstract

Apoptosis, a form of programmed cell death, plays a very crucial role in various physiological processes for maintaining cell homeostasis. This process has several characteristic features like membrane blebbing, nuclear condensation, DNA fragmentation and cell shrinkage. Any defect in this highly regulated process eventually leads to extended cell survival and could result in neoplastic cell expansion followed by genetic instability. The apoptotic machinery is mainly processed and regulated by various caspases, a family of cysteine proteases. Significant advancement has been made towards understanding the molecular mechanisms of apoptosis which provides new insights in modulating the life or death of a cell. The main goal of this review is to highlight recent updates on apoptosis, the cross-talk with other cellular death processes and its therapeutic potentials.

KEYWORDS:

Apoptosis; anoikis; autophagy; drug target; proteases; senescence.

[Indexed for MEDLINE]

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