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Neural Regen Res. 2018 Sep;13(9):1538-1541. doi: 10.4103/1673-5374.237111.

Utilizing zebrafish and okadaic acid to study Alzheimer's disease.

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Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH, USA.


Despite the many years of extensive research using rodent models to study Alzheimer's disease (AD), no cure or disease halting drug exists. An increasing number of people are suffering from the disease and a therapeutic intervention is needed. Therefore, it is necessary to have complementary models to aid in the drug discovery. The zebrafish animal model is emerging as a valuable model for the investigation of AD and neurodegenerative drug discovery. The main genes involved in human AD have homologous counterparts in zebrafish and have conserved function. The basic brain structure of the zebrafish is also conserved when compared to the mammalian brain. Recently an AD model was established by administering okadaic acid to zebrafish. It was used to test the efficacy of a novel drug, lanthionine ketimine-5-ethyl ester, and to elucidate its mechanism of action. This demonstrated the ability of the okadaic acid-induced AD zebrafish model to be implemented in the drug discovery process for therapeutics against AD.


Alzheimer's disease; Zebrafish; lanthionine ketimine-5-ethyl ester; learning and memory; okadaic acid; protein phosphatase 2A

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