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Biochem Biophys Res Commun. 2018 Sep 18;503(4):3078-3085. doi: 10.1016/j.bbrc.2018.08.096. Epub 2018 Aug 17.

Tannic acid inhibits NLRP3 inflammasome-mediated IL-1β production via blocking NF-κB signaling in macrophages.

Author information

1
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, 361102, China.
2
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, 361102, China; Department of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, 361004, China.
3
Respiratory Medicine, Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian, 361000, China.
4
Blood Transfusion Department, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, 361004, China.
5
Department of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, 361004, China; Department of Gastrointestinal Surgery, Institute of Gastrointestinal Oncology, Medical College of Xiamen University, Xiamen, Fujian, 361004, China. Electronic address: hongxu@xmu.edu.cn.
6
Department of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, 361004, China; Department of Gastrointestinal Surgery, Institute of Gastrointestinal Oncology, Medical College of Xiamen University, Xiamen, Fujian, 361004, China; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, 361102, China. Electronic address: jjhou@xmu.edu.cn.

Abstract

The NLRP3 inflammasome rapidly responds to many infections and stress signals and is involved in the pathogenesis of numerous inflammatory disease processes. Tannic acid plays a role in antioxidant, antifungal and antitumor activities. Here, we reported that tannic acid inhibited NLRP3 inflammasome activation by blocking NF-κB signaling to suppress IL-1β secretion. We found that the BMDMs (bone marrow-derived macrophages cells) pre-treated with tannic acid blocked caspase-1 cleavage and inhibited IL-1β secretion in a NLRP3-dependent manner, and suppressed NF-κB signaling activation by inhibiting NF-κB/P65 nuclear localization, suggesting that tannic acid inhibited NLRP3 inflammasome activation. These investigations revealed that tannic acid inhibited NLRP3 inflammasome activation via blocking NF-κB signaling in macrophages, providing us with evidence that tannic acid may be a potent inhibitor for NLRP3-driven diseases.

KEYWORDS:

Caspase-1; IL-1β; NF-κB/P65; NLRP3 inflammasome; Tannic acid

PMID:
30126633
DOI:
10.1016/j.bbrc.2018.08.096
[Indexed for MEDLINE]

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