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J Oncol Pharm Pract. 2018 Aug 20:1078155218792364. doi: 10.1177/1078155218792364. [Epub ahead of print]

Subcutaneous auto-administration of trastuzumab following therapeutic education: A case report.

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1 Department of Pharmacy, Institut BergoniƩ, Bordeaux, France.
2 Department of Oncology, Institut BergoniƩ, Bordeaux, France.


Trastuzumab is a monoclonal antibody used to treat human epidermal growth receptor 2 positive (HER2+) breast cancers either by itself or in combination with other chemotherapy medication. Marketing authorization was granted for a subcutaneous form of the antibody in 2014. In this case report, we discuss our experience with a patient who took part in a therapeutic education program on self-administration of trastuzumab. We demonstrate that these types of self-administered injections are not only possible but also are toxicity-free. Based on the tolerance data and our patient's experience, we propose that the current regulations be relaxed regarding the availability of trastuzumab subcutaneous form in order to develop a cheaper "city scheme," i.e. self-administered injections.


Breast cancer; monoclonal antibodies; self-administration


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