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Cancer Nurs. 2018 Aug 17. doi: 10.1097/NCC.0000000000000633. [Epub ahead of print]

Chinese Version of Pediatric Patient-Reported Outcomes Measurement Information System Short Form Measures: Reliability, Validity, and Factorial Structure Assessment in Children With Cancer in China.

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Author Affiliations: School of Nursing, Shanghai JiaoTong University, China (Dr Liu); School of Nursing, Fudan University (Dr Yuan), Shanghai, China; Division of Biostatistics and Study Methodology (Dr Wang), Department of Nursing Research and Quality Outcomes (Dr Hinds), Center for Translational Science, Children's National Health System, Washington, DC; School of Medicine, The George Washington University (Drs Wang and Hinds), Washington, DC; Nursing Department, Shanghai Children's Medical Center Affiliated to Shanghai JiaoTong University School of Medicine (Ms N. Shen), China; and Nursing Department, Children's Hospital of Soochow University (Ms M. Shen), Jiangsu, China.



The Pediatric Patient-Reported Outcomes Measurement Information System (PROMIS) was developed to measure symptoms and functions of children with a variety of chronic diseases. As the Chinese version of pediatric PROMIS (C-Ped-PROMIS) measures was developed, the measurement properties of C-Ped-PROMIS have not been demonstrated.


The aim of this study was to examine the reliability, validity, and factorial structure of the C-Ped-PROMIS measures in children with cancer in China.


A total of 272 children and adolescents were recruited from 3 hospitals in China. The 8 C-Ped-PROMIS measures and Pediatric Quality of Life Inventory General Core Module and Cancer Module were administered in a cross-sectional design. Known-group validity, concurrent validity, and item and scale reliability of these 8 measures were examined by using SPSS 21.0, and factorial structures were tested by using confirmatory factor analysis with Mplus 7.1.


All 8 C-Ped-PROMIS measures showed good known-group validity as hypothesized (P < .05) and good concurrent validity measured by significant correlations with the Pediatric Quality of Life Inventory General Core Module and Cancer Module; the correlation coefficients ranged from r = 0.519 to r = 0.655, except for peer relationship with r = 0.255 and r = 0.136, respectively. The Cronbach's α of C-Ped-PROMIS ranged from .758 to .910, and model-estimated scale reliabilities ranged from 0.740 to 0.905. The confirmatory factor analysis models of each measure fit data very well.


All 8 C-Ped-PROMIS measures have a valid factorial structure as theoretically defined with good reliability and validity.


The C-Ped-PROMIS can be readily used to measure symptoms and functions of children and adolescents with cancer in China.

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