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Pediatr Blood Cancer. 2019 Jan;66(1):e27407. doi: 10.1002/pbc.27407. Epub 2018 Aug 19.

Is the cancer survival improvement in European and American adolescent and young adults still lagging behind that in children?

Author information

1
Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
2
Institute of Cancer Sciences, University of Manchester, Manchester, UK.
3
Public Health Institute of Navarra, IdiSNA, Pamplona, Spain.
4
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
5
RiesSearch LLC, Rockville, Maryland.
6
Oregon Health and Science University, Portland, Oregon.
7
University of Texas Medical School at Houston, Houston, Texas.

Abstract

Improvements during 1978 to 2006 in the 5-year survival rate of adolescents and young adults (AYAs, age 15-39) and children with cancers common to both age groups were evaluated for 1978 to 2006 in Europe and the USA. AYAs had absolute survival increases of 25% and 15% in Europe and the USA, respectively, but in both cases, AYA 5-year survival was, as of 2006, 4% lower than those in children. Acute lymphoblastic leukemia (ALL) explained most of the survival difference between AYAs and children on both the continents. In the USA, 20- to 39-year-olds with ALL have had less survival improvement than those in Europe.

KEYWORDS:

acute lymphoblastic leukemia; adolescents and young adults; cancer; children; survival; time trends

PMID:
30124231
DOI:
10.1002/pbc.27407

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