Format

Send to

Choose Destination
Int J Med Sci. 2018 Jul 30;15(11):1217-1226. doi: 10.7150/ijms.26340. eCollection 2018.

Short-Term High-Dose Vitamin C and E Supplementation Attenuates Muscle Damage and Inflammatory Responses to Repeated Taekwondo Competitions: A Randomized Placebo-Controlled Trial.

Author information

1
Physical Education Office, National Taipei University of Technology, Taipei City, Taiwan.
2
Department of Chinese Martial Arts, Chinese Culture University, Taipei City, Taiwan.
3
Endurance Research Group, School of Sport and Exercise Sciences, University of Kent, Medway Campus, Chatham Maritime, UK.
4
Department of Exercise and Health Science, University of Taipei, Taipei City, Taiwan.
5
Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan.

Abstract

Background: Exercise-induced muscle damage during intensive sport events is a very common issue in sport medicine. Therefore, the purpose is to investigate the effects of short-term high-dose vitamin C and E supplementation on muscle damage, hemolysis, and inflammatory responses to simulated competitive Olympic Taekwondo (TKD) matches in elite athletes. Methods: Using a randomized placebo-controlled and double-blind study design, eighteen elite male TKD athletes were weight-matched and randomly assigned into either a vitamin C and E group (Vit C+E; N = 9) or placebo group (PLA; N = 9). Vit C+E or PLA supplements were taken daily (Vit C+E: 2000 mg/d vitamin C; 1400 U/d vitamin E) for 4 days (3 days before and on competition day) before taking part in 4 consecutive TKD matches on a single day. Plasma samples were obtained before each match and 24-hours after the first match for determination of markers of muscle damage, hemolysis, and systemic inflammatory state. Results: Myoglobin was lower in the Vit C+E group, compared to PLA, during the match day (area under curve, AUC -47.0% vs. PLA, p = 0.021). Plasma creatine kinase was lower in the Vit C+E group (AUC -57.5% vs. PLA, p = 0.017) and hemolysis was lower in the Vit C+E group (AUC -40.5% vs. PLA, p = 0.034). Conclusions: We demonstrated that short-term (4-days) vitamin C and E supplementation effectively attenuated exercise-induced tissue damage and inflammatory response during and after successive TKD matches.

KEYWORDS:

antioxidant; hemolysis; inflammation; muscle damage; myoglobin

PMID:
30123060
PMCID:
PMC6097262
DOI:
10.7150/ijms.26340
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Ivyspring International Publisher Icon for PubMed Central
Loading ...
Support Center