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Ann Indian Acad Neurol. 2018 Apr-Jun;21(2):164-165. doi: 10.4103/aian.AIAN_408_17.

Procerus Sign: Mechanism, Clinical Usefulness, and Controversies.

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Department of Neurology, Royal Cornwall Hospital NHS Trust, United Kingdom.


This sign is observed in atypical parkinsonism mainly in Progressive Supranuclear Palsy. The exact mechanism of this sign is not clear but the contraction of the Corrugator Supercilii muscle is the most important factor for the generation of vertical forehead creases. Though the wrinkling of forehead is a complex phenomenon involving multiple muscles but the 'Corrugator sign' would be a better term to describe this phenomenon. Despite the controversies regarding the mechanism and nomenclature, the 'Procerus sign' remains an important clinical clue for early Progressive Supranuclear palsy.


Corrugator supercilii; dystonia; glabella; procerus; progressive supranuclear palsy

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