Format

Send to

Choose Destination
Vaccine. 2018 Sep 11;36(38):5725-5731. doi: 10.1016/j.vaccine.2018.08.028. Epub 2018 Aug 16.

Assessment of one-dose mumps-containing vaccine effectiveness on wild-type genotype F mumps viruses circulating in mainland China.

Author information

1
WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, No. 155, Changbai Road, Changping District, Beijing 102206, People's Republic of China.
2
Shannxi Provincial Centers for Disease Control and Prevention, No. 3, Hepingwenwaijiandong Road, Xi'an 710054, People's Republic of China.
3
Jiangsu Provincial Centers for Disease Control and Prevention, No. 172, Jiangsu Road, Nanjing 210009, People's Republic of China.
4
China Center for Disease Control and Prevention, No. 155, Changbai Road, Changping District, Beijing 102206, People's Republic of China.
5
WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, No. 155, Changbai Road, Changping District, Beijing 102206, People's Republic of China. Electronic address: zhangyan9876543@163.com.
6
WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, No. 155, Changbai Road, Changping District, Beijing 102206, People's Republic of China. Electronic address: wenbo_xu1@aliyun.com.

Abstract

To clarify the protective effect of one-dose mumps-containing vaccines (MuCV) in mainland China, the antigenic variations of HN gene and cross-neutralization capacities between MuCV and wild type genotype F MuVs were studied. In total, 70 HN gene sequences of genotype F MuV representative strains obtained from 2001 to 2015, two types of MuCV strains, 139 pairs of pre- and post-vaccination serum samples from infants receiving one dose of MuCV vaccination were analyzed. Genotype-specific amino acid variations were observed in the potential antigenic epitopes between MuCV and wild-type genotype F MuVs circulating in mainland China. The mumps neutralization antibody titers induced by one-dose MuCV were found to be generally low. Moreover, significant differences in neutralization titers were observed between vaccine and wild-type strains. It could be concluded that one-dose MuCV had a cross-protective effect against the wild-type genotype F MuVs, but its effectiveness was limited, which might be caused by insufficient doses of MuCV vaccination and the genotype-specific antigenic differences between vaccine and wild-type MuVs as well. In addition, a poor linear correlation between mumps-specific IgG concentrations and neutralization titers was observed in this study, indicating the concentration of MuV-specific IgG could not fully reflect the neutralizing antibody titer in serum. Therefore, it is highly recommended to provide a second dose of MuCV to preschool children to increase MuV neutralizing antibody titers and use MuV cross-neutralization test as preferred tool for assessment of mumps-containing vaccine effectiveness on wild-type MuVs. This is the first report to assess the effectiveness of one-dose Chinese MuCV against wild-type genotype F MuVs, which would be benefit for the development of mumps vaccination strategy.

KEYWORDS:

Antigenic variation; Cross-neutralization; Mumps virus; Mumps-containing vaccine effectiveness

PMID:
30122648
DOI:
10.1016/j.vaccine.2018.08.028
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center