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Explore (NY). 2019 Mar - Apr;15(2):134-141. doi: 10.1016/j.explore.2018.07.007. Epub 2018 Jul 20.

Effect of Short-Term Interval Exercise Training on Fatigue, Depression, and Fitness in Normal Weight vs. Overweight Person With Multiple Sclerosis.

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Department of Sport Physiology, Tarbiat Modares University, Tehran, Iran.
Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Sport Physiology, Tarbiat Modares University, Tehran, Iran. Electronic address:
Department of Sport Physiology, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Neurology, Golstan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Physical Education, Abadan Branch, Islamic Azad University, Abadan, Iran.
Department for Molecular and Cellular Sports Medicine, German Sport University Cologne, Cologne, Germany; Division of Physical Activity, Prevention and Cancer, German Cancer Research Center, Heidelberg, Germany.
Institute of Clinical Exercise and Health Sciences, School of Science and Sport, University of the West of Scotland, Hamilton, Lanarkshire, Scotland.
School of Nursing, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.



Excessive weight is a health problem that can exacerbate multiple sclerosis (MS) symptoms and its associated comorbidities such as depression and fatigue. In addition, weight may be a moderator of exercise effects on depression and fatigue symptoms.


This study aimed to investigate the effects of exercise training on fatigue and depression in normal and overweight individuals with MS.


Sixty-six persons with MS were randomly assigned into an exercise or control condition based on body weight status (overweight vs. normal weight). The exercise conditions involved 8-weeks of interval exercise at 60%-75% Wattpeak, while the control condition did not involve any exercise. Fatigue, depression, aerobic capacity, time up and go (TUG) and body mass index were measured before and following the 8-week period.


There were no significant relationship's revealed for weight status interactions for any of the variables examined. There were significant condition main effects for fatigue, depression, aerobic capacity and TUG, and significant improvements were noted for the exercise conditions, but not in the non-exercising control group.


The results from this study confirm that exercise is an effective therapeutic intervention for improving fatigue, depression and functional parameters, independent of initial weight status, in persons with MS.


Depression; Excess weight; Fatigue; Fitness

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