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Clin Psychopharmacol Neurosci. 2018 Aug 31;16(3):324-332. doi: 10.9758/cpn.2018.16.3.324.

Neural Signature for Auditory Hallucinations in Schizophrenia: A High-Resolution Positron Emission Tomography Study with Fludeoxyglucose (18F).

Author information

1
Department of Psychiatry, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea.
2
Neuroscience Research Institute, Incheon, Korea.
3
Department of Biomedical Engineering, Gachon University, Incheon, Korea.
4
Research Institute for Advanced Industrial Technology, Korea University, Sejong, Korea.
5
Department of Computer Science and Engineering & Center for Advanced Image and Information Technology, Chonbuk National University, Jeonju, Korea.
6
Department of Psychiatry, Maeumsarang Hospital, Wanju, Korea.
7
Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
8
Departments of Radiology, Chonbuk National University Medical School, Jeonju, Korea.
9
Departments of Psychiatry, Chonbuk National University Medical School, Jeonju, Korea.

Abstract

Objective:

Auditory hallucinations (AHs) are a core symptom of schizophrenia. We investigated the neural signature of AHs by comparing hallucinating patients with schizophrenia with non-hallucinating patients with schizophrenia.

Methods:

We recruited hallucinating patients with schizophrenia meeting the criteria for persistent, prominent, and predominant AHs (n=10) and non-hallucinating patients with schizophrenia (n=12). Various clinical assessments were performed incluing Psychotic Symptom Rating Scale for Auditory Hallucinations. Using fludeoxyglucose (18F) positron emission tomography, regional differences in neural activity between the groups were analyzed.

Results:

The regions of interest analysis showed significantly lower standardized uptake value ratio (SUVR) in the superior, middle, and inferior frontal gyri, and higher SUVR in the putamen in patients with AHs versus patients without AHs. These findings were confirmed in the voxel-wise analysis.

Conclusion:

Our findings indicate that hypoactivity in the frontal and cingulate gyri, coupled with hyperactivity in the temporal gyrus and putamen, may contribute to the pathophysiology of AHs.

KEYWORDS:

Auditory hallucinations; Bottom-up; Positron-emission tomography; Schizophrenia; Top-down.

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