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Biomed Chromatogr. 2019 Jan;33(1):e4370. doi: 10.1002/bmc.4370. Epub 2018 Sep 30.

Methods and approaches for determination and enantioseparation of (RS)-propranolol.

Author information

1
Department of Basic and Applied Sciences, GD Goenka University, Gurgaon, India.
2
Department of Chemistry, Indian Institute of Technology Jammu, Jammu-181221, J&K, India.

Abstract

Propranolol, a β-adrenergic receptor antagonist, is a chiral compound that is marketed as a racemate, but only the (S)-(-)-enantiomer is responsible for the β-adrenoceptor blocking activity. Different chromatographic methods have been applied for separation and determination of enantiomers of (RS)-propranolol. In this article a review is presented on different liquid chromatographic methods used for enantioseparation of (RS)-propranolol, using both HPLC and TLC. In addition, some aspects of enantioseparation under achiral phases of liquid chromatography have been briefly mentioned.

KEYWORDS:

(RS)-propranolol; Enantioseparation; HPLC; TLC; chiral derivatization agents; chiral stationary phase; ligand exchange

PMID:
30121955
DOI:
10.1002/bmc.4370
[Indexed for MEDLINE]

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