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Dig Dis Sci. 2018 Dec;63(12):3187-3206. doi: 10.1007/s10620-018-5242-x. Epub 2018 Aug 18.

Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease.

Author information

1
Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, USA.
2
Division of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany.
3
Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, USA. Synw@musc.edu.
4
Section of Gastroenterology, Ralph H Johnson Veterans Affairs Medical Center, Charleston, USA. Synw@musc.edu.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in industrialized nations and is strongly associated with the metabolic syndrome. The prevalence of NAFLD continues to rise along with the epidemic of the metabolic syndrome. Metabolic homeostasis is linked to the circadian clock (rhythm), with multiple signaling pathways in organs regulated by circadian clock genes, and recent studies of circadian clock gene functions suggest that disruption of the circadian rhythm is associated with significant morbidity and mortality, including the metabolic syndrome. In the industrialized world, various human behaviors and activities such as work and eating patterns, jet lag, and sleep deprivation interfere with the circadian rhythm, leading to perturbations in metabolism and development of the metabolic syndrome. In this review, we discuss how disruption of the circadian rhythm is associated with various metabolic conditions that comprise the metabolic syndrome and NAFLD.

KEYWORDS:

Circadian rhythm; Diabetes mellitus; Fatty liver; Nonalcoholic steatohepatitis; Obesity

PMID:
30121811
DOI:
10.1007/s10620-018-5242-x

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