Kineret protein solution survives ten years

Yinghua Peng; Xiaohui Wang

doi:10.1016/j.jpba.2018.08.023

Kineret protein solution survives ten years

J Pharm Biomed Anal. 2018 Oct 25:160:383-385. doi: 10.1016/j.jpba.2018.08.023. Epub 2018 Aug 10.

Authors

Yinghua Peng¹, Xiaohui Wang²

Affiliations

¹ State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, Jilin 130112, China.
² Chemical Biology Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China; Department of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China. Electronic address: xiaohui.wang@ciac.ac.cn.

PMID: 30121556
DOI: 10.1016/j.jpba.2018.08.023

Abstract

Proteins are labile and their shelf lives are usually months to few years. Herein we report that human interleukin-1 receptor antagonist (IL-1Ra) solution survives ten years. This provides an interesting case that protein biopharmaceutical aqueous solution could be stored for a decade without losing its quality, which could meet the national security needs for 10 years shelf life of biopharmaceuticals.

Keywords: Biophysical chemistry; Interleukin-1 receptor antagonist; Protein aggregation; Protein stability; Shelf life.

MeSH terms

Drug Stability*
Humans
Interleukin 1 Receptor Antagonist Protein / analysis*
Solutions / chemistry
Time Factors

Substances

Interleukin 1 Receptor Antagonist Protein
Solutions