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Chem Biodivers. 2018 Oct;15(10):e1800144. doi: 10.1002/cbdv.201800144. Epub 2018 Oct 3.

Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells.

Author information

1
College of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea.
2
College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.

Abstract

Bioactivity-guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of 18 lathyrane-type diterpenoids including a new one, Euphorbia factor L29 (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D-NMR and HR-ESI-MS as well as CD data. All isolates (1 - 18) were found to inhibit the nitric oxide production in LPS-induced RAW 264.7 macrophages, with their IC50 values in the range of 11.2 - 52.2 μm.

KEYWORDS:

Euphorbia lathyris ; Euphorbiaceae; anti-inflammatory activities; lathyrane-type diterpenoids; nitric oxide

PMID:
30120899
DOI:
10.1002/cbdv.201800144
[Indexed for MEDLINE]

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