Format

Send to

Choose Destination
Bull Exp Biol Med. 2018 Aug;165(4):445-448. doi: 10.1007/s10517-018-4190-y. Epub 2018 Aug 18.

Combined Effect of NF-κB Inhibitor and β2-Adrenoreceptor Agonist on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis.

Author information

1
Saratov Medical University REAVIZ, Saratov, Russia. pfzabrodsky@gmail.com.
2
Saratov Medical University REAVIZ, Saratov, Russia.

Abstract

Experiments on random-bred albino mice showed that NF-κB inhibitor (BAY 11-7082) and β2-adrenoreceptor agonist (dexmedetomidine hydrochloride) significantly reduced mouse mortality in 4 and 24 h after sepsis modeling (intraperitoneal administration of E. coli) by reducing blood levels of proinflammatory cytokines TNFα, IL-1β, and IL-6. The combined administration of NF-κB inhibitor and β2-adrenoreceptors agonist have an additive effect.

KEYWORDS:

NF-κB inhibitor; agonist of β2-adrenoreceptors; cholinergic anti-inflammatory pathway; proinflammatory cytokines; sepsis

PMID:
30120665
DOI:
10.1007/s10517-018-4190-y
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center