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Biomed Pharmacother. 2018 Oct;106:1282-1291. doi: 10.1016/j.biopha.2018.07.079. Epub 2018 Jul 20.

Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine.

Author information

1
Department of Quality Assurance Techniques, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University (BVDU), Pune 411038, Maharashtra, India.
2
Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University (BVDU), Pune 411038, Maharashtra, India.
3
Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University (BVDU), Pune 411038, Maharashtra, India.
4
Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University (BVDU), Pune 411038, Maharashtra, India. Electronic address: pounbothi@yahoo.com.

Abstract

Fisetin (FIS), a bioactive flavonol found in the smoke tree (Cotinus coggygria), vegetables, fruits and nuts. It exhibits various therapeutic activities such as anti-oxidant, anti-inflammatory, anti-invasive, anti-tumorigenic, anti-angiogenic, anti-diabetic, cardioprotective and neuroprotective activities. In spite of the ever rising support for therapeutic activities, its clinical application is mainly limited because of poor water solubility, high lipophilicity and low oral bioavailability. Till date, numerous efforts have been made to surpass these limitations with the development of new improved delivery platforms. This article aims to review and analyze the various delivery strategies used to improve the biopharmaceutical properties of FIS. Furthermore, an attempt has been made to touch upon various features related to the progress of drug delivery including their influence on FIS chemistry, pharmacokinetics and other physicochemical attributes are discussed thoroughly.

KEYWORDS:

Drug delivery; Fisetin; Geraldol; Pharmacokinetic profile; Phytoconstituents

PMID:
30119198
DOI:
10.1016/j.biopha.2018.07.079
[Indexed for MEDLINE]

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