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Eur J Pharmacol. 2018 Oct 5;836:83-88. doi: 10.1016/j.ejphar.2018.08.015. Epub 2018 Aug 14.

Chrysin attenuates carrageenan-induced pleurisy and lung injury via activation of SIRT1/NRF2 pathway in rats.

Author information

1
Department of Nutrition, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, China.
2
HKBU Institute for Research and Continuing Education, Shenzhen, China.
3
Department of Neurology, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, China.
4
Department of Pharmacy, Zhejiang Hospital, Zhejiang Provincial Key Lab of Geriatrics, Hangzhou, China. Electronic address: zjyylili@163.com.
5
HKBU Institute for Research and Continuing Education, Shenzhen, China; Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai, China. Electronic address: zlybny@126.com.

Abstract

Chrysin, a natural polyphenol plentifully contained in honey, propolis, vegetables and fruits, it has been reported to exert a variety of pharmacological activities. In the present study, we mainly investigated the protective effects and underlying molecular mechanisms of chrysin on carrageenan-induced lung injury in rats. The results showed that chrysin inhibited the neutrophils infiltration, attenuated histological injury of lung tissues, decreased PMNs markers level and oxidative stress markers levels of lungs in rats. Further studies showed chrysin can inhibit the NF-кB activation in neutrophils cells, activate SIRT1/NRF2 pathway and reduce the expression of adhesion molecule in lung tissues. Taken together, these results suggested that chrysin can attenuate carrageenan-induced lung injury via inhibition of neutrophils activation and oxidative stress response, and that this attenuation is, at least partially, related to up-regulation of SIRT1/NRF2 signaling pathway. This study also validates SIRT1/NRF2 is an effective pharmacological target to protect against carrageenan-induced lung injury.

KEYWORDS:

Carrageenan; Chrysin; Lung injury; Neutrophils

PMID:
30118661
DOI:
10.1016/j.ejphar.2018.08.015
[Indexed for MEDLINE]

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