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J Am Acad Dermatol. 1986 May;14(5 Pt 2):915-7.

Subepidermal vesicular dermatosis and sensory peripheral neuropathy caused by pyridoxine abuse.


A woman who had ingested 2 gm of pyridoxine (vitamin B6) daily for 2 years for menstrual water retention developed a subepidermal vesicular eruption on the dorsa of the hands and toes, as well as a sensory peripheral neuropathy. The cutaneous and neurologic manifestations subsided about 2 months after discontinuation of the pyridoxine. The possible relationship of subepidermal vesicular eruptions caused by pyridoxine abuse to epidermolysis bullosa acquisita is discussed.

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