Contrast-Enhanced Transrectal Ultrasound for Follow-up After Focal HIFU Ablation for Prostate Cancer

J Ultrasound Med. 2019 Mar;38(3):811-819. doi: 10.1002/jum.14765. Epub 2018 Aug 16.

Abstract

The optimal strategy for imaging after focal therapy for prostate cancer is evolving. This series is an initial report on the use of contrast-enhanced transrectal ultrasound (TRUS) in follow-up of patients after high-intensity focused ultrasound (HIFU) hemiablation for prostate cancer. In 7 patients who underwent HIFU hemiablation, contrast-enhanced TRUS findings were as follows: (1) contrast-enhanced TRUS clearly showed the HIFU ablation defect as a sharply marginated nonenhancing zone in all patients; (2) contrast-enhanced TRUS identified suspicious foci of recurrent enhancement within the ablation zone in 2 patients, facilitating image-guided prostate biopsy, which showed prostate cancer; and (3) contrast-enhanced TRUS findings correlated with multiparametric magnetic resonance imaging and biopsy histologic findings.

Keywords: contrast-enhanced ultrasound; focal therapy; high-intensity focused ultrasound; prostate cancer; transrectal ultrasound.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Contrast Media*
  • Follow-Up Studies
  • High-Intensity Focused Ultrasound Ablation*
  • Humans
  • Image Enhancement / methods*
  • Male
  • Middle Aged
  • Prostate / diagnostic imaging
  • Prostate / surgery
  • Prostatic Neoplasms / diagnostic imaging*
  • Prostatic Neoplasms / surgery*
  • Treatment Outcome
  • Ultrasonography / methods*

Substances

  • Contrast Media