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Clin Cancer Res. 2019 Jan 1;25(1):6-8. doi: 10.1158/1078-0432.CCR-18-2177. Epub 2018 Aug 16.

CDK4/6 Inhibitors: What Is the Best Cocktail?

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Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.


CDK4/6 inhibitors have shown great potential in the new armamentarium against cancer. However, their effect as single agents is limited, and the hopes are on new combinatory strategies. Recent data suggest that inhibiting mTOR may significantly cooperate with cell-cycle arrest in a variety of cancers.See related article by Song et al., p. 403.

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