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Enferm Infecc Microbiol Clin. 2018 Sep;36 Suppl 1:15-18. doi: 10.1016/S0213-005X(18)30241-6.

Chronicity, ageing and multimorbidity.

[Article in English, Spanish]

Author information

1
Sección de Geriatría, Hospital Universitario Infanta Leonor, Madrid, España. Electronic address: fatima.branas@salud.madrid.org.
2
Centro de Salud Los Pintores, SERMAS, Parla, Madrid, España.
3
Psicología Clínica, Hospital Universitario Gregorio Marañón, Madrid, España.
4
Unidad de Enfermedades Infecciosas, Hospital Clínico Universitario, Santiago de Compostela, España.

Abstract

Thanks to highly active antiretroviral therapy (HAART), HIV-related mortality has been drastically reduced and HIV infection has become a chronic disease. The HIV-infected population is ageing prematurely. Despite good immunovirological control, HIV causes chronic inflammation and accelerated immunosenes-cence. This clinically manifests as an increased prevalence of age-related comorbidity and frailty occurring earlier than in the general population. The heterogeneity of older HIV-infected adults highlights the rele-vance of identifying those who are at risk of poor health, and frailty may be an effective indicator. The rela-tionship between ageing, HIV infection, antiretroviral treatment, comorbidities and frailty still needs to be clarified. Elderly HIV-infected adults are complex patients who require a specific, global and multidisci-plinary approach.

KEYWORDS:

Ageing; Chronicity; Comorbidity; Comorbilidad; Cronicidad; Envejecimiento; Fragilidad; Frailty; HIV infection; Infección por VIH

PMID:
30115402
DOI:
10.1016/S0213-005X(18)30241-6
[Indexed for MEDLINE]

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