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GMS Interdiscip Plast Reconstr Surg DGPW. 2018 Aug 3;7:Doc04. doi: 10.3205/iprs000124. eCollection 2018.

Pigmented (melanotic) diffuse neurofibroma of the back in neurofibromatosis type 1.

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Department of Oral and Craniomaxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Germany.
Institute of Neuropathology, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.


in English, German

Neurofibromatosis type 1 (NF1) is a tumor predisposition disease. Multiple neurofibromas are among the characteristic tumors of NF1. The report describes the diagnosis and treatment of a large spinal neurofibroma in a NF1 patient. The tumor showed a striking pigmentation and was diagnosed as pigmented (melanotic) neurofibroma. The distinction between this rare tumor variant and other pigmented tumors, especially malignant melanoma, is of primary importance.


diffuse neurofibroma; melanotic neurofibroma; neurofibromatosis type 1; pigmented neurofibroma

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