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Exp Ther Med. 2018 Aug;16(2):1323-1327. doi: 10.3892/etm.2018.6279. Epub 2018 Jun 8.

Relationship between ABCA1 gene polymorphism and lacunar infarction combined with arteriosclerosis in patients.

Xu Y1, Li Z2,3.

Author information

1
Department of Neurology, Ningbo First Hospital, Ningbo, Zhejiang 315010, P.R. China.
2
Department of Neurosurgery, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, Zhejiang 315040, P.R. China.
3
Department of Neurosurgery, Taipei Medical University Ningbo Medical Center, Ningbo, Zhejiang 315040, P.R. China.

Abstract

Adenosine triphosphate-binding cassette transporter A1 (ABCA1) gene polymorphism in lacunar infarction (LI) combined with arteriosclerosis was investigated. A total of 112 LI patients complicated with arteriosclerosis treated in Ningbo First Hospital from March 2015 to September 2016 were enrolled as observation group. At the same time, 342 healthy subjects were selected from physical examination center to serve as the control group. The ABCA1 gene polymorphism was detected via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and the susceptibility of ABCA1 gene to LI complicated with atherosclerosis was studied. There were no significant differences in serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and lipoprotein (a) [Lp(a)] between the two groups (P>0.05). Levels of triglyceride (TG) and apolipoprotein B (ApoB) in observation group were significantly higher than those in control group, but levels of ApoA-I and high-density lipoprotein cholesterol (HDL-C) were significantly lower in observation group than those in control group (P<0.05). There were no significant differences in the RR, RK and KK frequencies and allele frequency of ABCA1 R219K genotype between the two groups (P>0.05). Moreover, levels of HDL-C increased in the RR, RK and KK genotypes, but were not statistically significant (P>0.05). Levels of TG, TC, LDL-C, ApoA-I, ApoB and Lp(a) showed no significant differences among different genotypes of ABCA1 R219K (P>0.05). Results indicated that ABCA1 R219K polymorphism has no correlation with LI complicated with arteriosclerosis.

KEYWORDS:

ABCA1 gene; R219K; arteriosclerosis; lacunar infarction

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