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J Vet Med Sci. 2018 Nov 1;80(10):1553-1557. doi: 10.1292/jvms.18-0205. Epub 2018 Aug 16.

Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats.

Park JW1,2, Nam KT2,3, Shin JH1,2, Kim IY1,2, Choi KM1, Roh KJ1, Oh SH2,4, Yun YM5, Suh JG2,6, Oh YS6, Yoon YS2,7, Seong JK1,2,8.

Author information

1
Laboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
2
Korea Mouse Phenotyping Center (KMPC), 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
3
Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
4
College of Pharmacy, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si Gyeonggi-do, 13120, Korea.
5
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University, 61 Iljudong-ro, Jeju-si Jeju-do, 63294, Korea.
6
Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University, 1 Hallimdaehak-gil, Chuncheon-si, Gangwon-do, 24252, Korea.
7
Department of Anatomy and Cell Biology, BK21 Program Plus for Advanced Veterinary Science, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
8
Interdisciplinary Program for Bioinformatics, Program for Cancer Biology and BIO-MAX/N-Bio Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.

Abstract

Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of spontaneous pancreatitis in spontaneously hypertensive rats (SHRs), showing the formation of tubular complexes (TCs) and enhanced islet regeneration. We investigated the expression pattern of clusterin in the pancreas of SHRs based on immunohistochemistry (IHC). IHC analysis revealed the strong expression of clusterin in dedifferentiated duct-like cells and regenerative islets of TCs. These results imply that clusterin might be involved in the formation of TCs and parenchymal regeneration during rat pancreatitis.

KEYWORDS:

clusterin; pancreatitis; spontaneous hypertensive rat; tubular complex

PMID:
30111670
PMCID:
PMC6207517
DOI:
10.1292/jvms.18-0205
[Indexed for MEDLINE]
Free PMC Article

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