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Sci Transl Med. 2018 Aug 15;10(454). pii: eaam6003. doi: 10.1126/scitranslmed.aam6003.

Finding useful biomarkers for Parkinson's disease.

Author information

1
Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. chenplot@pennmedicine.upenn.edu.
2
Neurology Service and GRECC, VAAHS, Ann Arbor, MI 48105, USA.
3
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
4
Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
5
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.
6
Verily/Google Life Sciences, South San Francisco, CA 94080, USA.
7
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
8
Human Metabolome Technology-America, Boston, MA 02134, USA.
9
Biogen, Cambridge, MA 02142, USA.
10
Caprion Biosciences, Montreal, Quebec H2X 3Y7, Canada.
11
Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, MD 20892, USA.
12
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
13
Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
14
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
15
The Michael J. Fox Foundation for Parkinson's Research, New York, NY 10163, USA.
16
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
17
Department of Neurology, Penn State University-Hershey Medical Center, Hershey, PA 17033, USA.
18
Pharmaceutical Research and Early Development, NORD Discovery and Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.
19
Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA.
20
Departments of Cancer Biology and Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
21
Blais Proteomics Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
22
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
23
Chaperone Therapeutics, Portland, OR 97229, USA.
24
Paracelsus-Elena-Klinik, 34128 Kassel, Germany.
25
University Medical Center, 37075 Goettingen, Germany.
26
Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Chicago, IL 60064, USA.
27
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
28
Department of Neurology, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, New York, NY 10003, USA.
29
Center for Advanced Parkinson's Disease Research and Precision Neurology Program, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
30
Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
31
Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg.
32
Genentech, San Francisco, CA 94080, USA.
33
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
34
Department of Applied Physiology, Biomedical Engineering, and Neurology, University of Florida, Gainesville, FL 32611, USA.
35
Department of Neurology, University of Alabama, Birmingham, AL 35233, USA.
36
Department of Pathology, University of Washington, Seattle, WA 98195, USA.

Abstract

The recent advent of an "ecosystem" of shared biofluid sample biorepositories and data sets will focus biomarker efforts in Parkinson's disease, boosting the therapeutic development pipeline and enabling translation with real-world impact.

PMID:
30111645
PMCID:
PMC6097233
[Available on 2019-08-15]
DOI:
10.1126/scitranslmed.aam6003

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