Format

Send to

Choose Destination
Development. 2018 Aug 15;145(16). pii: dev163485. doi: 10.1242/dev.163485.

Human lung development: recent progress and new challenges.

Author information

1
Wellcome Trust/CRUK Gurdon Institute, Wellcome Trust/MRC Stem Cell Institute, Department of Pathology, University of Cambridge, Cambridge CB2 1QN, UK.
2
University of Cambridge School of Clinical Medicine, Department of Medicine, Cambridge CB2 0QQ, UK.
3
Wellcome Trust/CRUK Gurdon Institute, Wellcome Trust/MRC Stem Cell Institute, Department of Pathology, University of Cambridge, Cambridge CB2 1QN, UK e.rawlins@gurdon.cam.ac.uk.

Abstract

Recent studies have revealed biologically significant differences between human and mouse lung development, and have reported new in vitro systems that allow experimental manipulation of human lung models. At the same time, emerging clinical data suggest that the origins of some adult lung diseases are found in embryonic development and childhood. The convergence of these research themes has fuelled a resurgence of interest in human lung developmental biology. In this Review, we discuss our current understanding of human lung development, which has been profoundly influenced by studies in mice and, more recently, by experiments using in vitro human lung developmental models and RNA sequencing of human foetal lung tissue. Together, these approaches are helping to shed light on the mechanisms underlying human lung development and disease, and may help pave the way for new therapies.

KEYWORDS:

Alveolar; Bronchi; ESC; Lung disease; Progenitor; Stem cell; iPSC

PMID:
30111617
PMCID:
PMC6124546
DOI:
10.1242/dev.163485
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center