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Open Biol. 2018 Aug;8(8). pii: 180109. doi: 10.1098/rsob.180109.

Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis.

Author information

1
Oncode Institute, Hubrecht Institute - KNAW and University Medical Centre Utrecht, Utrecht, The Netherlands.
2
Oncode Institute, Hubrecht Institute - KNAW and University Medical Centre Utrecht, Utrecht, The Netherlands g.kops@hubrecht.eu.

Abstract

Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that ensure error-free chromosome segregation. As a result, Mps1 kinase activity has become an attractive candidate for pharmaceutical companies in the search for compounds that target essential cellular processes to eliminate, for example, tumour cells or pathogens. Research in recent decades has offered many insights into the molecular function of Mps1 and its regulation. In this review, we integrate the latest knowledge regarding the regulation of Mps1 activity and its spatio-temporal distribution, highlight gaps in our understanding of these processes and propose future research avenues to address them.

KEYWORDS:

Mps1; TTK; aneuploidy; chromosome segregation; kinetochore; spindle assembly checkpoint

PMID:
30111590
PMCID:
PMC6119859
DOI:
10.1098/rsob.180109
[Indexed for MEDLINE]
Free PMC Article

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