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J Microbiol Biotechnol. 2018 Aug 28;28(8):1391-1400. doi: 10.4014/jmb.1805.05065.

Suppressive Effect of Fermented Angelica tenuissima Root Extract against Photoaging: Possible Involvement of Hemeoxygenase-1.

Author information

1
Department of Herbal Medicine Resource, Kangwon National University, Samcheok 25949, Republic of Korea.
2
Department of Convergence Biomedical Science, Cardiovascular and Metabolic Disease Center, College of Medicine, Inje University, Busan 47392, Republic of Korea.
3
Department of Medicinal and Industrial Crops, Korea National College of Agriculture and Fisheries, Jeonju 54874, Republic of Korea.
4
Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 17104, Republic of Korea.
5
Chungbuk Technopark, Cheongju 28115, Republic of Korea.
6
Korea Research Institute Bio Science Co., Ltd., Yeoju 12668, Republic of Korea.

Abstract

Angelica tenuissima root has historically been used as a traditional medicine in Korea. Previous studies have identified the anti-melanogenic effects of the extract of A. tenuissima root fermented by Aspergillus oryzae (FAT). This study investigated the protective effects of FAT against ultraviolet light B exposure (UVB; 30 mJ/cm2) in HaCaT (human keratinocyte) or Hs68 (human foreskin fibroblast) skin cells. FAT treatment was able to stimulate wound healing rate at the basal condition. FAT also favored the maintenance and/or improvement of extracellular matrix impairment caused by UVB irradiation through: 1) upregulation of procollagen Type-1 synthesis and secretion; 2) suppression of MMP-1 and elastase expression. FAT was able to play a role in the attenuation of inflammatory responses caused by UVB irradiation via upregulation of photo-protective hemeoxygease-1 and suppression of proinflammatory cyclooxygenase-2 expression. After further verification of the anti-photoaging potential of FAT, it could be utilized as an effective ingredient in anti-aging and anti-wrinkle cosmetics.

KEYWORDS:

Angelica tenuissima; extracellular matrix; fermentation; hemeoxygenase-1; photoaging; ultraviolet light B

PMID:
30111075
DOI:
10.4014/jmb.1805.05065
[Indexed for MEDLINE]
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