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Acta Cir Bras. 2018 Jul;33(7):565-576. doi: 10.1590/s0102-865020180070000002.

Rectal application of argan oil improves healing of colorectal anastomosis in rats1.

Author information

1
MD, General Surgeon, Ankara Education and Research Hospital, Department of General Surgery, Ankara, Turkey. Conception and design of the study.
2
Associate Professor, Ankara Education and Research Hospital, Department of General Surgery, Ankara, Turkey. Design of the study and analysis of data.
3
Associate Professor, Ankara Education and Research Hospital, Department of General Surgery, Ankara, Turkey. Design of the study and manuscript writing.
4
Associate Professor, Ankara Education and Research Hospital, Department of General Surgery, Ankara, Turkey. Critical revision.
5
MD, General Surgeon, Ankara Education and Research Hospital, Department of General Surgery, Ankara, Turkey. Design of the study.
6
Associate Professor, Ankara Education and Research Hospital, Department of Biochemistry, Ankara, Turkey. Performed the biochemical analyses.
7
MD, Biochemist, Ankara Education and Research Hospital, Department of Biochemistry, Ankara, Turkey. Performed the biochemical analyses.
8
MD, Pathologist, Ankara Education and Research Hospital, Department of Pathology, Ankara, Turkey. Histopathological examinations.
9
MD, General Surgeon, Ankara Education and Research Hospital, Department of General Surgery, Ankara, Turkey. Conception of the study and interpretation of data.
10
Full Professor, Ankara Education and Research Hospital, Department of Pathology, Ankara, Turkey. Histopathological examinations.

Abstract

PURPOSE:

To investigate the possible effects of argan oil on the healing of colorectal anastomoses.

METHODS:

n Group 1 (sham), laparotomy was performed and the colon was mobilized. In the control (Group 2) and argan oil (Group 3) groups, colonic resection and anastomosis were applied. To the control and sham groups, 2 mL of 0.9% NaCl was administred rectally, and in the argan oil group, 2 mL/day argan oil was applied rectally for 7 days.

RESULTS:

The mean bursting pressures of the argan oil and sham groups were significantly higher than the values in the control group. A significant difference was determined between the tissue hydroxyproline and prolidase levels of control group and other groups. Histopathologically, argan oil showed significant beneficial effects on colonic wound healing. In the argan oil and sham groups, the tissue malondialdehyde and fluorescent oxidation product levels were found to be lower and total sulfhydryl levels were higher than the control group.

CONCLUSIONS:

The rectally administered argan oil was observed to have significantly ameliorated wound healing parameters and exerted a significant antioxidant effect. This is the first study in the literature about the beneficial effects of argan oil on colorectal anastomoses.

[Indexed for MEDLINE]
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