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Appl Microbiol Biotechnol. 2018 Oct;102(20):8685-8705. doi: 10.1007/s00253-018-9289-6. Epub 2018 Aug 14.

Recent advances in metabolic engineering of Corynebacterium glutamicum for bioproduction of value-added aromatic chemicals and natural products.

Author information

1
Research Institute of Innovative Technology for the Earth, 9-2, Kizugawadai, Kizugawa, Kyoto, 619-0292, Japan.
2
Research Institute of Innovative Technology for the Earth, 9-2, Kizugawadai, Kizugawa, Kyoto, 619-0292, Japan. inui@rite.or.jp.
3
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan. inui@rite.or.jp.

Abstract

Recent progress in synthetic and systems metabolic engineering technologies has explored the potential of microbial cell factories for the production of industrially relevant bulk and fine chemicals from renewable biomass resources in an eco-friendly manner. Corynebacterium glutamicum, a workhorse for industrial amino acid production, has currently evolved into a promising microbial platform for bioproduction of various natural and non-natural chemicals from renewable feedstocks. Notably, it has been recently demonstrated that metabolically engineered C. glutamicum can overproduce several commercially valuable aromatic and related chemicals such as shikimate, 4-hydroxybenzoate, and 4-aminobenzoate from sugars at remarkably high titer suitable to commercial application. On the other hand, overexpression and/or extension of its endogenous metabolic pathways by integrating heterologous metabolic pathways enabled production of structurally intricate and valuable natural chemicals like plant polyphenols, carotenoids, and fatty acids. In this review, we summarize recent advances in metabolic engineering of C. glutamicum for production of those value-added aromatics and other natural products, which highlights high potential and the versatility of this microbe for bioproduction of diverse chemicals.

KEYWORDS:

Aromatic compounds; Corynebacterium glutamicum; Metabolic engineering; Plant polyphenols; Shikimate pathway; Terpenoids

PMID:
30109397
DOI:
10.1007/s00253-018-9289-6
[Indexed for MEDLINE]

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