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Mech Ageing Dev. 2018 Oct;175:83-87. doi: 10.1016/j.mad.2018.08.002. Epub 2018 Aug 11.

Cellular senescence in osteoarthritis and anti-aging strategies.

Author information

1
Orthopedics Research Institute of Chinese PLA, Beijing Key Lab of Regenerative Medicine in Orthopedics, General Hospital of Chinese PLA, Fuxing Road 28, Haidian District, Beijing 100853, PR China; Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan 030012, PR China.
2
Orthopedics Research Institute of Chinese PLA, Beijing Key Lab of Regenerative Medicine in Orthopedics, General Hospital of Chinese PLA, Fuxing Road 28, Haidian District, Beijing 100853, PR China.
3
Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan 030012, PR China. Electronic address: zym2166@126.com.
4
Orthopedics Research Institute of Chinese PLA, Beijing Key Lab of Regenerative Medicine in Orthopedics, General Hospital of Chinese PLA, Fuxing Road 28, Haidian District, Beijing 100853, PR China. Electronic address: pengjiang301@126.com.

Abstract

In older adults, the prevalence of osteoarthritis (OA) increases directly with age and is the most common cause of chronic disability. It is necessary to recognize that OA is a degenerative disease that strongly correlates with age, and often promotes elevated levels of cartilage injury. Chondrocytes undergo an age-dependent decline in proliferative and synthetic capacity. It is thought that cellular senescence may play a significant role in the pathology of OA, with chondrocytes exhibiting a variety of senescence-associated phenotypes. In this review, we discuss cellular senescence and its relationship with OA. More importantly, we introduce novel strategies for the modulation of cellular senescence, including the use of sirtuin 6, mammalian target of rapamycin, N-acetyl-l-cysteine, proteoglycan-4 and senolytic, which may help to delay senescence and improve cartilage regeneration in the aging population.

KEYWORDS:

Aging; Cellular senescence; Chondrocytes; Osteoarthritis; Treatment

PMID:
30107185
DOI:
10.1016/j.mad.2018.08.002
[Indexed for MEDLINE]

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