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Chem Biol Interact. 2018 Dec 25;296:9-17. doi: 10.1016/j.cbi.2018.08.005. Epub 2018 Aug 11.

Protective effects of apigenin against 3-MCPD-induced renal injury in rat.

Author information

1
College of Food Science and Engineering, Northwest A & F University, Yangling, Shaanxi, 712100, China; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University(BTBU), Beijing, 100048, China.
2
College of Food Science and Engineering, Northwest A & F University, Yangling, Shaanxi, 712100, China.
3
College of Food Science and Engineering, Northwest A & F University, Yangling, Shaanxi, 712100, China; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University(BTBU), Beijing, 100048, China. Electronic address: pxlpxh@163.com.
4
College of Food Science and Engineering, Northwest A & F University, Yangling, Shaanxi, 712100, China. Electronic address: pxlpxh@163.com.

Abstract

Apigenin (API) is a kind of important flavonoid present in temperate and tropical fruit and vegetables, especially the celery. It exerts anticancer, anti-bacterial, anti-viral, anti-inflammatory, anti-oxidation properties. In the present study, the mechanism of protective action of apigenin on 3-chloro-1, 2-propanediol (3-MCPD)-induced renal injury was investigated in rat. Sprague-Dawley (SD) rats were divided into five groups: control group (ultrapure water treated), CMC group (sodium carboxymethylcellulose treated), 3-MCPD treatment group (30 mg/kg body weight/day), 3-MCPD plus API co-treatment group (20, 40 mg/kg body weight/day). The results showed that API significantly reduced renal function markers, serum creatinine and urea nitrogen content. Besides, the renal tissue lesion in 3-MCPD treatment group was restored by API to some extent. We indicated that API exerted renoprotective effect by modulating oxidative phosphorylation especially up-regulated the expressions of ATP6 and ATP8, re-establishing mitochondrial membrane potential (MMP), relieving the increase of Bax/Bcl2 ratio, reducing cytochrome c release, thus inhibiting the activation of Caspase 9 and Caspase 3. In conclusion, apigenin possesses excellent protective effect against 3-MCPD-induced renal injury by modulating mitochondria dependent Caspase cascade pathway.

KEYWORDS:

3-MCPD; Apigenin; Apoptosis; Caspase; Mitochondrial dysfunction; Renal injury

PMID:
30107153
DOI:
10.1016/j.cbi.2018.08.005
[Indexed for MEDLINE]

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