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Br J Nutr. 2018 Oct;120(7):751-762. doi: 10.1017/S0007114518001824. Epub 2018 Aug 14.

7-Hydroxymatairesinol improves body weight, fat and sugar metabolism in C57BJ/6 mice on a high-fat diet.

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1Clinical Chemistry Laboratory,Diagnostic Department,ASST Spedali Civili di Brescia,P. Le Spedali Civili 1, 25123 Brescia,Italy.
3Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER),"Bruno Ubertini", Via Bianchi, 9, 25124 Brescia,Italy.
4Human Pathology,School of Medicine,University of Brescia,P. Le Spedali Civili 1, 25123 Brescia,Italy.
2Department of Molecular and Translational Medicine,University of Brescia,Via Valsabbina 1, 25123 Brescia,Italy.
5Linnea SA,via Cantonale 123,CH-6595 Riazzino,Switzerland.
6Laboratory of Industrial Toxicology,Department of Medicine and Surgery,University of Parma,43126 Parma,Italy.
7Department of Medical and Surgical Specialties,Radiological Sciences and Public Health,Section of Public Health and Human Sciences,University of Brescia,P. Le Spedali Civili 1, 25123 Brescia,Italy.
8Laboratory of Wood and Paper Chemistry,Åbo Akademi University,20500 Turku,Finland.


7-Hydroxymatairesinol (7-HMR) is a plant lignan abundant in various concentrations in plant foods. The objective of this study was to test HMRLignan™, a purified form of 7-HMR, and the corresponding Picea abies extract (total extract P. abies; TEP) as dietary supplements on a background of a high-fat diet (HFD)-induced metabolic syndrome in mice and in the 3T3-L1 adipogenesis model. Mice, 3 weeks old, were fed a HFD for 60 d. Subgroups were treated with 3 mg/kg body weight 7-HMR (HMRLignan™) or 10 mg/kg body weight TEP by oral administration. 7-HMR and TEP limited the increase in body weight (-11 and -13 %) and fat mass (-11 and -18 %) in the HFD-fed mice. Epididymal adipocytes were 19 and -12 % smaller and the liver was less steatotic (-62 and -65 %). Serum lipids decreased in TEP-treated mice (-11 % cholesterol, -23 % LDL and -15 % TAG) and sugar metabolism was ameliorated by both lignan preparations, as shown by a more than 70 % decrease in insulin secretion and insulin resistance. The expression of several metabolic genes was modulated by the HFD with an effect that was reversed by lignan. In 3T3-L1 cells, the 7-HMR metabolites enterolactone (ENL) and enterodiol (END) showed a 40 % inhibition of cell differentiation accompanied by the inhibited expression of the adipogenic genes PPARγ, C/EBPα and aP2. Furthermore, END and ENL caused a 10 % reduction in TAG uptake in HEPA 1-6 hepatoma cells. In conclusion, 7-HMR and TEP reduce metabolic imbalances typical of the metabolic syndrome and obesity in male mice, whereas their metabolites inhibit adipogenesis and lipid uptake in vitro.


7-HMR 7-hydroxymatairesinol; DMSO dimethylsulfoxide; END enterodiol; ENL enterolactone; HFD high-fat diet; LFD low-fat diet; PA palmitic acid; TEP total Picea abies extract; TFEB transcription factor EB; 7-Hydroxymatairesinol; Adipocyte differentiation; Adipose deposition; Lignan; Metabolism; Obesity


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