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Nat Rev Microbiol. 2018 Dec;16(12):760-773. doi: 10.1038/s41579-018-0070-8.

Targeting mechanisms of tailed bacteriophages.

Author information

1
Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands.
2
Laboratory of Microbiology, Wageningen University, Wageningen, Netherlands.
3
Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, Netherlands.
4
Laboratory of Gene Technology, KU Leuven, Leuven, Belgium.
5
Centre for Molecular and Biomolecular Informatics, Radboud University Medical Centre, Nijmegen, Netherlands.
6
Department of Marine Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
7
Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands. stanbrouns@gmail.com.
8
Laboratory of Microbiology, Wageningen University, Wageningen, Netherlands. stanbrouns@gmail.com.

Abstract

Phages differ substantially in the bacterial hosts that they infect. Their host range is determined by the specific structures that they use to target bacterial cells. Tailed phages use a broad range of receptor-binding proteins, such as tail fibres, tail spikes and the central tail spike, to target their cognate bacterial cell surface receptors. Recent technical advances and new structure-function insights have begun to unravel the molecular mechanisms and temporal dynamics that govern these interactions. Here, we review the current understanding of the targeting machinery and mechanisms of tailed phages. These new insights and approaches pave the way for the application of phages in medicine and biotechnology and enable deeper understanding of their ecology and evolution.

PMID:
30104690
DOI:
10.1038/s41579-018-0070-8

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