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BMJ Open. 2018 Aug 13;8(8):e021719. doi: 10.1136/bmjopen-2018-021719.

Validation of the ICH score in patients with spontaneous intracerebral haemorrhage admitted to the intensive care unit in Southern Spain.

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Intensive Care Medicine, Hospital de la Serranía, Ronda, Spain.
Programa de Doctorado, Universidad de Granada, Granada, Spain.
Intensive Care Medicine, Hospital Virgen de las Nieves, Granada, Spain.
Neurosurgery Department, Hospital del Mar, Barcelona, Spain.
Intensive Care Medicine, Hospital Infanta Margarita, Cabra, Spain.
Intensive Care Medicine, Hospital Carlos Haya, Málaga, Spain.
Cardiology Department, Hospital Virgen de las Nieves, Granada, Spain.
Neurosurgery Department, Hospital Carlos Haya, Málaga, Spain.
Intensive Care Medicine, Complejo Hospitalario de Jaén, Jaén, Spain.



Validation of the intracerebral haemorrhage (ICH) score in patients with a diagnosis of spontaneous ICH admitted to the intensive care unit (ICU).


A multicentre cohort study was conducted in all consecutive patients with ICH admitted to the ICUs of three hospitals with a neurosurgery department between 2009 and 2012 in Andalusia, Spain. Data collected included ICH, Glasgow Coma Scale (GCS) and Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores. Demographic data, location and volume of haematoma and 30-day mortality rate were also collated.


A total of 336 patients were included. 105 of whom underwent surgery. Median (IQR) age: 62 (50-70) years.


21(15-26) points, GCS: 7 (4-11) points, ICH score: 2 (2-3) points. 11.1% presented with bilateral mydriasis on admission (mortality rate=100%). Intraventricular haemorrhage was observed in 58.9% of patients. In-hospital mortality was 54.17% while the APACHE-II predicted mortality was 57.22% with a standardised mortality ratio (SMR) of 0.95 (95% CI 0.81 to 1.09) and a Hosmer-Lemenshow test value (H) of 3.62 (no significant statistical difference, n.s.). 30-day mortality was 52.38% compared with the ICH score predicted mortality of 48.79%, SMR: 1.07 (95% CI 0.91 to 1.23), n.s. Mortality was higher than predicted at the lowest scores and lower than predicted in the more severe patients, (H=55.89, p<0.001), Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva calibration belt (p<0.001). The area under a receiver operating characteristic (ROC) curve was 0.74 (95% CI 0.69 to 0.79).


ICH score shows an acceptable discrimination as a tool to predict mortality rates in patients with spontaneous ICH admitted to the ICU, but its calibration is suboptimal.


ICH score; ICU; intracerebral haemorrhage; mortality; prognostic model

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