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Diabetes. 2018 Nov;67(11):2329-2336. doi: 10.2337/db18-0355. Epub 2018 Aug 13.

Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes.

Collaborators (209)

Rewers M, Bautista K, Baxter J, Felipe-Morales D, Driscoll K, Frohnert BI, Gallant M, Gesualdo P, Hoffman M, Karban R, Liu E, Norris J, Samper-Imaz A, Steck A, Waugh K, Wright H, Toppari J, Simell OG, Adamsson A, Ahonen S, Hyöty H, Ilonen J, Jokipuu S, Karlsson L, Kähönen M, Knip M, Koreasalo M, Kurppa K, Latva-Aho T, Lönnrot M, Mattila M, Mäntymäki E, Multasuo K, Niininen T, Niinistö S, Nyblom M, Ollikainen P, Rajala P, Rautanen J, Riikonen A, Romo M, Ruohonen S, Rönkä J, Simell S, Simell T, Sjöberg M, Stenius A, Vainionpää S, Varjonen E, Veijola R, Virtanen SM, Vähä-Mäkilä M, Åkerlund M, Lindfors K, She JX, Schatz D, Hopkins D, Steed L, Bryant J, Adams J, Silvis K, Haller M, Gardiner M, McIndoe R, Sharma A, Anderson SW, Jacobsen L, Marks J, Towe PD, Ziegler AG, Beyerlein A, Bonifacio E, Gavrisan A, Gezginci C, Heublein A, Hummel M, Hummel S, Knopff A, Koch C, Koletzko S, Ramminger C, Roth R, Scholz M, Stock J, Warncke K, Wendel L, Winkler C, Lernmark Å, Agardh D, Aronsson CA, Ask M, Bremer J, Carlsson UM, Cilio C, Ericson-Hallström E, Fors A, Fransson L, Gard T, Bennet R, Hansson C, Hyberg S, Jisser H, Johansen F, Jonsdottir B, Jovic S, Elding Larsson H, Lindström M, Lundgren M, Månsson-Martinez M, Markan M, Melin J, Mestan Z, Nilsson C, Ottosson K, Rahmati K, Ramelius A, Salami F, Sibthorpe S, Sjöberg A, Sjöberg B, Törn C, Wallin A, Wimar Å, Åberg S, Hagopian WA, Killian M, Crouch CC, Skidmore J, Akramoff A, Banjanin J, Chavoshi M, Dunson K, Hervey R, Lyons R, Meyer A, Mulenga D, Radtke J, Schmitt D, Schwabe J, Zink S, Becker D, Franciscus M, Dalmagro-Elias Smith M, Daftary A, Klein MB, Yates C, Krischer JP, Austin-Gonzalez S, Avendano M, Baethke S, Brown R, Burkhardt B, Butterworth M, Clasen J, Cuthbertson D, Eberhard C, Fiske S, Garcia D, Garmeson J, Gowda V, Heyman K, Hsiao B, Laras FP, Lee HS, Liu S, Liu X, Lynch K, Maguire C, Malloy J, McCarthy C, Merrell A, Meulemans S, Parikh H, Quigley R, Remedios C, Shaffer C, Smith L, Smith S, Sulman N, Tamura R, Toth M, Uusitalo U, Vehik K, Vijayakandipan P, Wood K, Yang J, Yu L, Miao D, Bingley P, Williams A, Chandler K, Ball O, Kelland I, Grace S, Gillard B, Hagopian W, Chavoshi M, Radtke J, Schwabe J, Erlich H, Mack SJ, Fear AL, Ke S, Mulholland N, Akolkar B, Bourcier K, Briese T, Johnson SB, Triplett E.

Author information

1
Department of Clinical Sciences, Lund University/Clinical Research Centre, Skåne University Hospital, Malmö, Sweden falastin.salami@med.lu.se.
2
Health Informatics Institute, Department of Pediatrics, University of South Florida, Tampa, FL.
3
Department of Medical Sciences, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
4
Department of Clinical Sciences, Lund University/Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.

Abstract

Islet autoantibodies (IAs) precede the clinical onset of type 1 diabetes (T1D); however, the knowledge is limited about whether the prodrome affects complete blood counts (CBCs) in 4- to 12-year-old children with increased genetic risk for T1D. This study tested whether CBCs were altered in 4- to 12-year-old children without (n = 376) or with one or several IAs against insulin, GAD65, or IA-2 (n = 72). CBC was analyzed during longitudinal follow-up in 448 Swedish children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study. A linear mixed-effects model was used to assess potential association between IA and CBC measurements over time. The white blood cell and neutrophil counts were reduced in children with IAs, primarily in boys. In contrast, girls had lower levels of hemoglobin and hematocrit. Positivity for multiple IAs showed the lowest counts in white blood cells and neutrophils in boys and red blood cells, hemoglobin, and hematocrit in girls. These associations were primarily observed in children with the HLA-DR3-DQ2/DR4-DQ8 genotype. We conclude that the reduction in neutrophils and red blood cells in children with multiple IAs and HLA-DR3-DQ2/DR4-DQ8 genotype may signal a sex-dependent islet autoimmunity detected in longitudinal CBCs.

PMID:
30104249
PMCID:
PMC6198343
[Available on 2019-11-01]
DOI:
10.2337/db18-0355
[Indexed for MEDLINE]

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