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Prostaglandins Leukot Essent Fatty Acids. 2018 Aug;135:63-73. doi: 10.1016/j.plefa.2018.07.006. Epub 2018 Jul 18.

Role of metabolic programming in the modulation of microglia phagocytosis by lipids.

Author information

1
INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux 33076, France; University Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux 33076, France. Electronic address: agnes.nadjar@u-bordeaux.fr.

Abstract

Microglia phagocytosis is an essential process to maintain lifelong brain homeostasis and clear potential toxic factors from the neuropil. Microglia can engulf cells or part of cells through the expression of specific receptors at their surface and activation of downstream signaling pathways to engulf material. Microglia phagocytosis is finely regulated and is under the dependence of many factors, including environmental cues such as dietary lipids. Yet, the molecular mechanisms implicated are still largely unknown. The present publication is a 'hypothesis review', assessing the possibility that lipid-mediated modulation of phagocytosis occurs by affecting bioenergetic pathways within microglia. I assess our present knowledge and the elements that allow drawing such hypothesis. I also list some of the important gaps in the literature that need to be filled in. I also consider opportunities for future therapeutic target including nutritional interventions.

KEYWORDS:

Bioenergetics; Fatty acid; Fatty acid oxidation; Fatty acid synthase; Glycolysis; Immunometabolism; Inflammation; Lipid metabolism; Microglia; Mitochondria; Pentose phosphate pathway; Phagocytosis

PMID:
30103935
DOI:
10.1016/j.plefa.2018.07.006
[Indexed for MEDLINE]

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