Format

Send to

Choose Destination
Int J Mol Sci. 2018 Aug 10;19(8). pii: E2361. doi: 10.3390/ijms19082361.

Phytochemicals in Helicobacter pylori Infections: What Are We Doing Now?

Author information

1
Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran 88777539, Iran. bahar.salehi007@gmail.com.
2
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 22439789, Iran. bahar.salehi007@gmail.com.
3
Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan. shfarukh@mail.ru.
4
Nutrition and Dietetics Department, Faculty of Pharmacy, University of Concepción, Concepción, 4070386 VIII⁻Bio Bio Region, Chile. mmartorell@udec.cl.
5
Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, 11129 Belgrade, Serbia. jolarajkovic@yahoo.com.
6
Functional Foods, Nutraceuticals and Phytomedicine Unit, Department of Biochemistry, Federal University of Technology, Akure 340252, Nigeria. ademiluyidayo@yahoo.co.uk.
7
Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663335, Iran. m.sharifirad@zbmu.ac.ir.
8
Department of Biochemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon. tsouh80@yahoo.fr.
9
Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. ncmartins@med.up.pt.
10
Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal. ncmartins@med.up.pt.
11
Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy. marcello.iriti@unimi.it.
12
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran. javad.sharifirad@gmail.com.
13
Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada. javad.sharifirad@gmail.com.

Abstract

In this critical review, plant sources used as effective antibacterial agents against Helicobacter pylori infections are carefully described. The main intrinsic bioactive molecules, responsible for the observed effects are also underlined and their corresponding modes of action specifically highlighted. In addition to traditional uses as herbal remedies, in vitro and in vivo studies focusing on plant extracts and isolated bioactive compounds with anti-H. pylori activity are also critically discussed. Lastly, special attention was also given to plant extracts with urease inhibitory effects, with emphasis on involved modes of action.

KEYWORDS:

Helicobacter pylori; anti-urease activity; in vitro/in vivo findings; opportunistic colonization; phytopharmacology; plant products

PMID:
30103451
PMCID:
PMC6121492
DOI:
10.3390/ijms19082361
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center